Fractalkine and inflammatory diseases
نویسندگان
چکیده
منابع مشابه
Fractalkine and in‰ammatory diseases
The migration of leukocytes into in‰amed peripheral tissues and lymphoid organs involves a cascade of molecular events ˆnely regulated by cell adhesion molecules and chemokines. Fractalkine/CX3CL1 is a membrane-bound chemokine that functions not only as a chemoattractant but also as an adhesion molecule, and is expressed on endothelial cells activated by proin‰ammatory cytokines. The fractalkin...
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Inflammatory and immune responses are generated locally by the selective invasion and accumulation of the immune cells into the lesion site. The infiltration process of the immune cells into the tissue from the blood through the vascular endothelial cells is closely regulated by a number of chemotactic factors and cell adhesion molecules. Fractalkine (FKN)/CX3CL1 is a membrane-bound chemokine p...
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Peripheral blood smear study is very useful tool in early diagnosis of some infection and inflammatory diseases. In present article morphological changes of blood cells will be discussed in general infection and in viral infection such as HIV, H1N1 influenza and parvovirus B19. Physiologic and emergency granulopoesis will also be discussed.
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The role of inflammation in neurodegenerative diseases has been widely demonstrated. Intraneuronal protein accumulation may regulate microglial activity via the fractalkine (CX3CL1) signaling pathway that provides a mechanism through which neurons communicate with microglia. CX3CL1 levels fluctuate in different stages of neurodegenerative diseases and in various animal models, warranting furthe...
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Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell nucleus and affects gene transcription. IL-37 inhibits the phosphorylation of p38 mitogen-activated pr...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 2005
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.28.131